Microscopic Colitis.
10.3904/kjm.2015.89.6.663
- Author:
Han Seung RYU
1
;
Suck Chei CHOI
Author Information
1. Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea. medcsc@wonkwang.ac.kr
- Publication Type:Review
- Keywords:
Microscopic colitis;
Collagenous colitis;
Lymphocytic colitis;
Inflammatory bowel disease
- MeSH:
Autoimmunity;
Bacteria;
Colitis, Collagenous;
Colitis, Lymphocytic;
Colitis, Microscopic*;
Colitis, Ulcerative;
Crohn Disease;
Diagnosis;
Diarrhea;
Epidemiologic Studies;
Genetic Predisposition to Disease;
Inflammatory Bowel Diseases;
Myofibroblasts;
Phenobarbital;
Quality of Life
- From:Korean Journal of Medicine
2015;89(6):663-671
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Microscopic colitis (MC) is a chronic idiopathic inflammatory bowel disease presenting with chronic watery diarrhea. Epidemiologic studies from Western countries have demonstrated that it is almost as common as other classic inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Histological examination can confirm the diagnosis and differentiate between the two main subtypes of MC: collagenous colitis and lymphocytic colitis. The pathophysiology of MC remains unknown; however, possible etiologies include genetic predispositions, autoimmunity, inflammatory responses to luminal factors such as certain drugs or bacteria, and myofibroblast dysregulations. The aim of MC therapy should take into account the severity of symptoms, impact on quality of life, and evidence from clinical trials of available medical treatments.
