Association between Change in Body Weight and Insulin Resistance in Individuals at Increased Risk of Diabetes.
10.3904/kjm.2015.89.6.681
- Author:
Kyung Jin CHOE
1
;
Won Jun KIM
;
Sa Young SHIN
;
Yeongmin WOO
;
Ki Hun LEE
;
Eun Jung KIM
;
Myoung Sook SHIM
;
Jin Yeob KIM
Author Information
1. Department of Internal Medicine, Gangneung Asan Hospital, Ulsan University College of Medicine, Gangneung, Korea. kozmozman@gnah.co.kr
- Publication Type:Original Article
- Keywords:
Increased risk for diabetes (prediabetic state);
Obesity;
Insulin resistance
- MeSH:
Body Mass Index;
Body Weight*;
Diagnosis;
Endocrinology;
Fasting;
Female;
Humans;
Insulin Resistance*;
Insulin*;
Male;
Obesity;
Obesity, Abdominal;
Overweight;
Prevalence;
Retrospective Studies;
Waist Circumference
- From:Korean Journal of Medicine
2015;89(6):681-689
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The present study aimed to investigate the associations between a change in body weight from 20 years of age to the present with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes. METHODS: From patients with a diagnosis related to an increased risk of diabetes who were examined at our endocrinology clinic from January 2012 to December 2014, the present study recruited 125 individuals between 30 and 64 years of age with hemoglobin A1c levels from 5.7 to 6.4%. The change in body weight of each patient from 20 years of age to the present was retrospectively determined, and the associations of this change with insulin resistance and several parameters of metabolic syndrome were analyzed. RESULTS: The average gain in body weight after 20 years of age was 11.3 kg and there was no significance difference between the male and female patients. The proportion of overweight and obese patients at 20 years of age was 14%, but was 74% at the time of the visits to our endocrinology clinic. A change in body weight was significantly correlated with body mass index, insulin resistance, and waist circumference. Additionally, as the tertile of change in body weight increased, fasting insulin levels, insulin resistance, and the prevalence of abdominal obesity significantly increased. CONCLUSIONS: In the present study, an increase in body weight from 20 years of age to the present was correlated with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes.
