IgG4-related Disease Controlled by a Low-dose Steroid and Mycophenolic Acid.
10.3904/kjm.2015.89.6.690
- Author:
Ji Eun KIM
1
;
Jin Joo CHA
;
Sun Woo KIM
;
Yu Ah HONG
;
Gang Jee KO
;
Young Joo KWON
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. yjkwon@korea.ac.kr
- Publication Type:Case Report
- Keywords:
IgG4;
Mycophenolic acid;
MPA;
Eosinophilia
- MeSH:
Appetite;
Cyclophosphamide;
Dizziness;
Eosinophilia;
Humans;
Immunoglobulin G;
Male;
Middle Aged;
Mycophenolic Acid*;
Pancreatitis;
Prednisolone;
Steroids;
Thyroid Gland;
Thyroiditis
- From:Korean Journal of Medicine
2015;89(6):690-694
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
IgG4-related disease (IgG4-RD) is a group of fibro-inflammatory diseases affecting multiple organ systems, pathologically characterized by tissue infiltration with abundant IgG4-positive cells. We here report a case of IgG4-RD that was successfully controlled by mycophenolic acid (MPA). A 62-year-old male visited complaining of dizziness and loss of appetite. He had a clinical history of autoimmune pancreatitis treated with steroids and cyclophosphamide 5 years prior, and had also been diagnosed with Hashimoto's thyroiditis at the age of 55 years. We initially prescribed prednisolone (1 mg/kg), tapered to 5 mg/day over 8 months. However, his eosinophilia gradually deteriorated, and we added cyclophosphamide (1 mg/kg daily) for the next 7 months. His laboratory data fluctuated when he was on low-dose predinisolone and cyclophosphamide, and we thus changed his medication to prednisolone combined with MPA for the following 63 months. Currently, his laboratory findings are stable.
