Immunohistochemical Study of Expression of Involucrin, Loricrin, Filaggrin and Bcl-2 in Psoriasis.
- Author:
Kyung Dal KIM
1
;
Hyun Jin KIM
;
Nack In KIM
Author Information
1. Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. pibu@nuri.net
- Publication Type:Original Article
- Keywords:
Psoriasis;
Involucrin;
Loricrin;
Filaggrin;
Bcl-2
- MeSH:
Apoptosis;
Cell Death;
Epidermis;
Keratinocytes;
Psoriasis*;
Skin
- From:Korean Journal of Dermatology
2002;40(5):506-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The pathogenesis of psoriasis remains uncertain. It is known that a variety of factors take a role in its pathogenesis. One of them is the alteration of keratinocytes differentiation. The terminal differentiation of keratinocytes includes the process of the synthesis of proteins such as involucrin, filaggrin, loricrin and cornifin, and produce keratohyaline granules and a structure termed cornified cell envelope finally. And the terminal differentiation of keratinocytes is known as a process of apoptosis, programmed cell death. OBJECTIVE: In this study, we tried to clarify the pathogenetic mechanisms of psoriasis by comparing the expression patterns of several proteins(involucrin, loricrin, filaggrin) associated with keratinocyte differentiation and of bcl-2 protein, known as inhibitor of apoptosis, between lesional and non-lesional psoriatic skin. RESULTS: The results were summarized as follows, firstly early expression of involucrin in lower epidermis, secondly no or reduced expression of filaggrin and loricrin in upper epidermis and lastly no expression of bcl-2 in basal layer of psoriatic skin. CONCLUSION: This study clarified that the accelerated terminal differentiation, the shortening of cell-cycle of keratinocytes, and the increased turnover of keratinocytes may be involved in the pathogenetic role of psoriasis.
