A Case of Subcutaneous Panniculitic T Cell Lymphoma.
- Author:
Eun Phil HEO
1
;
Won Sup LEE
;
Chee Won OH
Author Information
1. Department of Dermatology, College of Medicine, Gyeongsang National University, Chinju, Korea.
- Publication Type:Case Report
- Keywords:
Subcutaneous panniculitic T-cell lymphoma;
Cytophagic histiocytic panniculitis;
Epstein-Barr virus
- MeSH:
Adult;
Alanine;
Anemia;
Biopsy;
Buttocks;
Diagnosis;
Disease Progression;
Extremities;
Follow-Up Studies;
Genome;
Herpesvirus 4, Human;
Humans;
In Situ Hybridization;
Leukopenia;
Lymphatic Diseases;
Lymphohistiocytosis, Hemophagocytic;
Lymphoma, T-Cell*;
Lymphoma, T-Cell, Peripheral;
Panniculitis;
Skin;
T-Lymphocytes;
Transferases
- From:Korean Journal of Dermatology
2002;40(5):545-550
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Subcutaneous panniculitic T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-cell lymphoma that clinically and histologically mimics benign panniculitis. It represents subcutaneous nodules predominantly on extremities and trunk and hemophagocytic syndrome almost leading to death. Recent reports suggest that cytophagic histiocytic panniculitis(CHP) and SPTCL may span a clinicopathologic spectrum in which there is a natural disease progression from CHP to SPTCL. We report a 41-year-old Korean man who presented with recurrent tender erythematous subcutaneous nodules on the buttock and extremities for 13 years history. There was no hepatosplenomegaly or lymphadenopathy. Laboratory data revealed mild anemia, leukopenia, and elevated alanine transferase. Epstein-Barr virus(EBV) serological values evidenced chronic active infection. His skin biopsy specimen showed lobular panniculitis with atypical lymphohistiocytic inflammatory infiltrates. The inflammatory infiltrates expressed CD45RO, CD3, CD4, CD8, and CD68. But CD20 and CD56 were negative. In situ hybridization studies for the EBV genome showed negative finding. This case presents SPTCL that had eluded diagnosis for a long time. It also suggests the importance of continued follow-up with repeated biopsy, in case of long course of recurrent tender erythematous nodules and histological lobular lymphocytic panniculitis.
