Low-dose UVA1 Phototherapy for Localized Scleroderma.
- Author:
Nyoung Hoon YOUN
1
;
Dong O YOO
;
Seung Hoon CHA
;
Seok Don PARK
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, korea. dermcha@hanmail.net
- Publication Type:Case Report
- Keywords:
Localized scleroderma;
UVA1 phototherapy
- MeSH:
Adolescent;
Apoptosis;
Collagen;
Dermis;
Female;
Fibroblasts;
Humans;
Matrix Metalloproteinase 1;
Phototherapy*;
RNA, Messenger;
Scleroderma, Localized*;
Sclerosis;
Skin;
T-Lymphocytes;
Thigh
- From:Korean Journal of Dermatology
2002;40(5):551-554
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Localized scleroderma(LS) is sclerosis of the skin characterized by one or multiple circumscribed ivory-white, indurated, sometimes confluent plaques. It has been reported that LS might result from the unbalance between synthesis and degradation of collagen in the dermis. Recently, treatment of LS with long wave UVA1, which can induce mRNA of matrix metalloproteinase-1 from dermal fibroblast and can cause apoptosis of infiltrating T lymphocytes, showed promising results. In this case, a 14-year-old girl had a 6 month history of linear, brown colored, indurated plaque on her left thigh compatible with LS histopathologically. UVA1(2.4-10.8J/cm2) was irradiated to the skin lesion at each visit, a total of 68 times for 18 months with the cumulative dose of 533J/cm2 UVA1. Her fibrotic skin lesion was resolved during treatment, but became hardened with cessation of phototherapy. She remains disease free for 11 months. We report a case of LS with improvement with low-dose UVA1 phototherapy.
