Successful Treatment of Two Cases of Keratoacanthomas with Intralesional Methotrexate.
- Author:
Dong O YOU
1
;
Nyoung Hoon YOUN
;
Seok Don PARK
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, korea. sdpark@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Keratoacanthoma;
Methotrexate
- MeSH:
Injections, Intralesional;
Keratoacanthoma*;
Methotrexate*
- From:Korean Journal of Dermatology
2002;40(5):555-558
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Keratoacanthoma is a rapidly growing tumor that has the tendency of spontaneous involution but it may persist for some times, continue to enlarge and may become invasive and destructive. Many modalities are available for the treatment of keratoacanthoma. Although excisional surgery is the treatment of choice, this can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. We report two cases with unusually large or facial keratoacanthoma treated with intralesional methotrexate. One case showed complete resolution over 6 injections and the other after 2 injections. We suggest that intralesional injection of methotrexate is a simple, effective, safe and inexpensive method for the treatment of large keratoacanthoma.
