The Effects of Magnesium Supplementation for Correcting Hypokalemia in Gitelman Syndrome.
- Author:
Joong Don MOON
1
;
Sang Woong HAN
;
Ho Jung KIM
Author Information
1. Division of Nephrology, Guri Hospital, College of Medicine, Hanyang University, Guri, Korea. kimhj@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Gitelman syndrome;
Hypokalemia;
Magnesium;
Hypomagnesemia
- MeSH:
Alkalosis;
Blood Pressure;
Gitelman Syndrome*;
Humans;
Hyperaldosteronism;
Hypokalemia*;
Magnesium*;
Potassium;
Spironolactone;
Gitelman Syndrome
- From:Korean Journal of Nephrology
2006;25(2):213-220
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGOUND: Gitelman's syndrome is manifested by hypokalemia, metabolic alkalosis, normal blood pressure, hyperreninemic hyperaldosteronism, hypomagnesemia and hypocalciuria. This study was carried out to investigate the effects of magnesium supplementation for correcting hypokalemia in Gitelman syndrome. METHODS: A Gitelman patient without hyperaldosteronism in our hospital was studied, oral supplementation periods of regimens for 60 days were divided into eight stages (each stage is at least over 5 days) such as 1 stage:no regimen supplementation period 2 stage:spironolactone 100 mg, alone period 3 stage:spironolactone 100 mg, MgO 1 g mixed period, 4 stage:spironolactone 100 mg, alone period, 5 stage:spironolactone 100 mg, MgO 1 g mixed period, 6 stage:spironolactone 150 mg, MgO 1 g mixed period, 7 stage: spironolactone 150 mg, MgO 1.5 g mixed period, 8 stage:spironolactone 150 mg, MgO 1.5 g, KCl 3.6 g mixed period. RESULTS: The highest value of plasm [K] was 3.3 mEq/L, the lowest value of TTKG was 2.6 during 3 stage, plasm [K] had tendency to increased and TTKG decreased, however next during 4 stage, the tendency of correcting hypokalemia diminished. The highest value of plasm [K] was only 3.3 mEq/L during 7 stage, the highest value of plasm [K] was 4.6 mEq/L during 8 stage. And the highest value of plasm ionized [Mg++] was 0.44 mmol/L during MgO 1.5 g supplementation. CONCLUSION: Magnesium alone fails to completely correct potassium and magnesium depletion despite tendency of correcting. Therefore, the optimal therapeutic regimens for correcting hypokalemia in Gitelman syndrome without hyperaldosteronism would be the magnesium and additional K supplementation.
