Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.
10.4062/biomolther.2015.090
- Author:
Xirali TURSUN
1
;
Yongxin ZHAO
;
Zulfiya TALAT
;
Xuelei XIN
;
Adila TURSUN
;
Rahima ABDULLA
;
Haji AKBERAISA
Author Information
1. Key Laboratory of Chemistry of Plant Resources in Arid Regions, China. haji@ms.xjb.ac.cn
- Publication Type:Original Article
- Keywords:
Rosa rugosa Thunb;
Inflammation;
Nuclear factor-κB;
Mitogen-activated protein kinases
- MeSH:
Dinoprostone;
Far East;
Flowers*;
Inflammation;
Interleukins;
Macrophages*;
Mitogen-Activated Protein Kinases;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Phenol;
Rosa*;
Stomach;
Tumor Necrosis Factor-alpha
- From:Biomolecules & Therapeutics
2016;24(2):184-190
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rosa rugosa Thunb, a deciduous shrub of the genus Rosa, has been widely used to treat stomach aches, diarrhoea, pain, and chronic inflammatory disease in eastern Asia. In recent years, our research team has extensively studied the Rosa rugosa flower extract, and specifically undertook pharmacological experiments which have optimized the extraction process. Our methods have yielded a standard extract enriched in phenolic compounds, named PRE. Herein, we expand our efforts and evaluated the anti-inflammatory activity of PRE on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. PRE significantly inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-a, interleukin (IL)-6, and interleukin 1β (IL-1β), as well as expression of their synthesizing enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX-2). Furthermore, PRE inhibited activity of mitogen-activated protein kinases (MAPK) as well as nuclear factor-kappa B (NF-κB) signaling pathway. Our findings are the first to explain the anti-inflammatory mechanism by PRE in LPS-stimulated macrophages. Given these results, we propose that PRE has therapeutic potential in the prevention of inflammatory disorders.
