Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass.
- Author:
Young Nam YOUN
1
;
Seong Yong PARK
;
Yoohwa HWANG
;
Huyn Chul JOO
;
Kyung Jong YOO
Author Information
1. Division of Cardiovascular Surgery, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Korea. kjy@yuhs.ac
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Off-pump;
Coronary artery bypass;
Statin
- MeSH:
Angina, Stable;
Coronary Artery Bypass;
Coronary Artery Bypass, Off-Pump;
Creatine;
Fluorobenzenes;
Humans;
Incidence;
Myocardial Ischemia;
Myocardial Revascularization;
Pyrimidines;
Risk Factors;
Sulfonamides;
Transplants;
Trinitrotoluene;
Troponin T;
Rosuvastatin Calcium
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2011;44(3):208-214
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions. We aimed to assess the efficacy of high-dose rosuvastatin loading in patients with stable angina undergoing off-pump coronary artery bypass grafting (OPCAB). MATERIALS AND METHODS: A total of 142 patients with stable angina who were scheduled to undergo surgical myocardial revascularization were randomized to receive either pre-treatment with 60-mg rosuvastatin (rosuvastatin group, n=71) or no pre-treatment (control group, n=71) before OPCAB. The primary endpoint was the 30-day incidence of major adverse cardiac events (MACEs). The secondary endpoint was the change in the degree of myocardial ischemia as evaluated with creatine kinase-myocardial band (CK-MB) and troponin T (TnT). RESULTS: There were no significant intergroup differences in preoperative risk factors or operative strategy. MACEs within 30 days after OPCAB occurred in one patient (1.4%) in the rosuvastatin group and four patients (5.6%) in the control group, respectively (p=0.37). Preoperative CK-MB and TnT were not different between the groups. After OPCAB, the mean maximum CK-MB was significantly higher in the control group (rosuvastatin group 10.7+/-9.75 ng/mL, control group 14.6+/-12.9 ng/mL, p=0.04). Furthermore, the mean levels of maximum TnT were significantly higher in the control group (rosuvastatin group 0.18+/-0.16 ng/mL, control group 0.39+/-0.70 ng/mL, p=0.02). CONCLUSION: Our findings suggest that high-dose rosuvastatin loading before OPCAB surgery did not result in a significant reduction of 30-day MACEs. However, high-dose rosuvastatin reduced myocardial ischemia after OPCAB.
