Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma.
- Author:
Shin Ok JEONG
1
;
Eui Bae KIM
;
Soung Won JEONG
;
Jae Young JANG
;
Sae Hwan LEE
;
Sang Gyune KIM
;
Sang Woo CHA
;
Young Seok KIM
;
Young Deok CHO
;
Hong Soo KIM
;
Boo Sung KIM
;
Yong Jae KIM
;
Dong Erk GOO
;
Su Yeon PARK
Author Information
- Publication Type:Original Article
- Keywords: Carcinoma, hepatocellular; Chemoembolization, therapeutic; Complete response; Recurrence
- MeSH: Carcinoma, Hepatocellular*; Chemoembolization, Therapeutic; Humans; Multivariate Analysis; Recurrence*; Venous Thrombosis
- From:Gut and Liver 2017;11(3):409-416
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). METHODS: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). RESULTS: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p<0.001), respectively. Elevated serum α-fetoprotein (AFP) (>20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p<0.001), respectively. Tumor size (>5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS. CONCLUSIONS: In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.
