Effects of Keto Acids on Serum Albumin Level in Hemodialysis Patients with Hypoalbuminemia.
- Author:
Sook Eui OH
1
;
Young Ki LEE
;
Jin Kyung KIM
;
Dong Hun LEE
;
Soo Jin KIM
;
Sung Gyun KIM
;
Ji Eun OH
;
Jang Won SEO
;
Jong Woo YOON
;
Ja Ryong KOO
;
Hyung Jik KIM
;
Jung Woo NOH
Author Information
1. Department of Internal Medicine, Kidney Research Institute, College of Medicine Hallym University, Seoul, Korea. km2071@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Hemodialysis;
Keto acids;
Albumin
- MeSH:
Amino Acids, Essential;
Dialysis;
Humans;
Hypercalcemia;
Hypoalbuminemia;
Keto Acids;
Liver Cirrhosis;
Malnutrition;
Multivariate Analysis;
Renal Dialysis;
Serum Albumin
- From:Korean Journal of Nephrology
2010;29(1):82-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Malnutrition is a strong predictor of increased morbidity and mortality in patients on maintenance dialysis. Although a number of studies were performed to determine effective treatment, there is no proven medication for malnutrition. This study aimed to evaluate the effect of keto acids (ketosteril(R)) on serum albumin levels in hemodialysis patients with hypoalbuminemia. METHODS: Hemodialysis patients with hypoalbumineia (serum albumin < or = 3.8 g/dL) were enrolled. Exclusion criteria were previous supplementation of keto acids before the initiation of dialysis, acute infection, liver cirrhosis, malignancy and persistent hypercalcemia. Patients were treated with ketosteril for 6 months and serum albumin levels were compared to age- and gender-matched hemodialysis patients. RESULTS: There were no significant differences in the baseline serum albumin levels between ketosteril group (n=19) and the control group (n=19). After 6 months, the mean (+/-SD) serum albumin level in the ketosteril group rose from 3.46+/-0.40 g/dL to 3.66+/-0.37 g/dL (p=0.01), but not the control group. However, the difference between the two groups was not significant (p=0.06). Multivariate analysis showed that the ketosteril supplementation (p=0.03) and the baseline serum albumin level (< or = 3.4 g/dL, p=0.04) were predictors of increased serum albumin. There was no severe hypercalcemia during the study period. CONCLUSION: There was an improvement of serum albumin levels in hemodialysis patients with hypoalbuminemia after the supplementation of keto acids.
