Three Cases of Minimal Change Nephrotic Syndrome in Patients with Type 2 Diabetes.
- Author:
Jun Seok JEON
1
;
Jung Eun LEE
;
Jin Hee LEE
;
Byeongho JEONG
;
A Jin CHO
;
Gee Young KWON
;
Wooseong HUH
;
Yoon Goo KIM
;
Dae Joong KIM
;
Ha Young OH
Author Information
1. Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine, Korea. jungeun34.lee@samsung.com
- Publication Type:Case Report
- Keywords:
Nephrotic syndrome;
minimal change;
Type 2 diabetes mellitus;
Corticosteroid
- MeSH:
Diabetes Mellitus, Type 2;
Diabetic Nephropathies;
Diagnosis, Differential;
Electrons;
Foot;
Humans;
Hypertension;
Light;
Nephrosis, Lipoid;
Nephrotic Syndrome;
Proteinuria
- From:Korean Journal of Nephrology
2010;29(1):104-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Diabetic nephropathy is a common and serious complication of diabetes characterized by persistent proteinuria, hypertension and a progressive decline of renal function. However, non-diabetic renal disease can be present in diabetic patients and differential diagnosis of treatable disease is important. Minimal change nephrotic syndrome is characterized by normal light microscopic finding and effacement of foot process in electron microscope, but foot process effacement is not specific and it can be present in the glomeruli of the most glomerulopathy including diabetic nephropathy. Therefore, pathologic diagnosis of minimal change nephrotic syndrome combined with diabetic nephropathy is very difficult. However, we could exclude other glomerulopathy and diagnose minimal change nephrotic syndrome by clinical features in three type 2 diabetic patients with diabetic nephropathy and have successfully treated with corticosteroid.
