Cardiopulmonary Bypass in Patient with Heparin-Induced Thrombocytopenia Employing Recombinant Hirudin.
10.4097/kjae.2000.39.2.270
- Author:
Wol Son CHUNG
1
;
Chun Hyeong PARK
;
Ji Yeon SIM
;
Jae Won LEE
;
In Cheol CHOI
Author Information
1. Department of Anesthesiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Complications: heparin induced thrombocytopenia;
Heart: cardiopulmonary bypass;
Hemorrhage: hirudin
- MeSH:
Blood Platelets;
Cardiopulmonary Bypass*;
Diuresis;
Heparin;
Hirudins*;
Humans;
Platelet Transfusion;
Thrombin;
Thrombocytopenia*;
Thromboembolism;
Thrombosis
- From:Korean Journal of Anesthesiology
2000;39(2):270-274
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Heparin-induced thrombocytopenia (HIT) is a heparin-dependent antibody-mediated platelet activating syndrome frequently accompanying thrombocytopenia, thromboembolism. We experienced a case of cardiopulmonary bypass using hirudin, a direct thrombin inhibitor, in a patient with HIT. The patient who showed thrombocytopenia and thrombosis after heparin re-exposure was highly suspected of having HIT. Hirudin was used in this case as an anticoagulating agent during cardiopulmonary bypass (CPB) to prevent serious complications of heparin. Hirudin 0.3 mg/kg was mixed with a priming solution of CPB and a 0.2 mg/kg IV bolus followed by a continuous infusion of hirudin 0.15 mg/kg given for anticoagulation. After CPB, forced diuresis and platelet transfusion was performed and the patient was recovered without complication.
