Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.
10.3349/ymj.2015.56.6.1545
- Author:
Seung Hyun LEE
1
;
Kihyuk SHIN
;
Sungha PARK
;
Seok Min KANG
;
Donghoon CHOI
;
Seung Hyo LEE
;
Sang Hak LEE
Author Information
1. Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. shl1106@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Elastin;
antibody formation;
vascular stiffness;
coronary artery disease;
atherosclerosis
- MeSH:
Aged;
Angiography;
Antibodies/*blood;
Atherosclerosis/*blood/immunology;
Coronary Artery Disease/blood/*immunology;
Elastin/*blood/immunology;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Hyperlipidemias;
Hypertension/complications;
Male;
Middle Aged;
Pulse Wave Analysis;
Vascular Stiffness/*immunology/physiology
- From:Yonsei Medical Journal
2015;56(6):1545-1551
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Elastin is a major arterial structural protein, and elastin-derived peptides are related to arterial change. We previously reported on a novel assay developed using aortic elastin peptides; however, its clinical implications remain unclear. In this study, we assessed whether anti-elastin antibody titers reflect the risk of coronary artery disease (CAD) or its characteristics. MATERIALS AND METHODS: We included 174 CAD patients and 171 age- and sex-matched controls. Anti-elastin antibody titers were quantified by enzyme-linked immunosorbent assay. Parameters of arterial stiffness, including the augmentation index (AI) and heart-to-femoral pulse wave velocity (hfPWV), were measured non-invasively. The clinical and angiographic characteristics of CAD patients were also evaluated. Associations between anti-elastin levels and vascular characteristics were examined by linear regression analysis. RESULTS: The median blood level of anti-elastin was significantly lower in the CAD group than in the controls [197 arbitrary unit (a.u.) vs. 63 a.u., p<0.001]. Levels of anti-elastin were significantly lower in men and in subjects with hypertension, diabetes mellitus, hyperlipidemia, or high hfPWV. Nevertheless, anti-elastin levels were not dependent on atherothrombotic events or the angiographic severity of CAD. In a multivariate analysis, male sex (beta=-0.38, p<0.001), diabetes mellitus (beta=-0.62, p<0.001), hyperlipidemia (beta=-0.29, p<0.001), and AI (beta=-0.006, p=0.02) were ultimately identified as determinants of anti-elastin levels. CONCLUSION: Lower levels of anti-elastin are related to CAD. The association between antibody titers and CAD is linked to arterial stiffness rather than the advancement of atherosclerosis.
