Prostate Specific Membrane Antigen mRNA in Blood as a Potential Predictor of Biochemical Recurrence after Radical Prostatectomy.
10.3346/jkms.2010.25.9.1291
- Author:
Jae Young JOUNG
1
;
Kang Su CHO
;
Han Soo CHUNG
;
In Chang CHO
;
Jung Eun KIM
;
Ho Kyung SEO
;
Jinsoo CHUNG
;
Weon Seo PARK
;
Moon Kyung CHOI
;
Kang Hyun LEE
Author Information
1. Center for Prostate Cancer, Goyang, Korea. uroonco@ncc.re.kr
- Publication Type:Original Article ; Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Prostate Specific Membrane Antigen;
Biochemical Recurrence;
Prostatic Neoplasms
- MeSH:
Aged;
Antigens, Surface/*blood/genetics;
Glutamate Carboxypeptidase II/*blood/genetics;
Humans;
Male;
Middle Aged;
Neoplasm Recurrence, Local/blood/*diagnosis;
Predictive Value of Tests;
*Prostatectomy;
Prostatic Neoplasms/blood/*diagnosis/surgery;
RNA, Messenger/*blood;
Reverse Transcriptase Polymerase Chain Reaction;
Severity of Illness Index;
Time Factors
- From:Journal of Korean Medical Science
2010;25(9):1291-1295
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated whether the detection of prostate specific membrane antigen (PSMA) in blood preoperatively has predictive value for biochemical recurrence (BCR) after radical prostatectomy in patients with prostate cancer. All 134 patients scheduled to receive radical prostatectomy for prostate cancer were prospectively enrolled. The authors used nested reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect PSMA mRNA-bearing cells in peripheral blood, and analyzed the ability of PSMA mRNA positivity to predict BCR after surgery. PSMA-mRNA was detected in 24 (17.9%) patients by RT-PCR. Over a median follow-up of 20 months (range, 3 to 46 months), BCR developed in 15 patients (11.2%) and median time to BCR was 7 months (range, 3 to 25 months). Kaplan-Meier analysis revealed a significant difference between those positive or negative for PSMA in terms of recurrence-free actuarial probability (log rank P=0.0039). Multivariate analysis showed that positivity for PSMA mRNA (HR: 3.697, 95% CI 1.285-10.634, P=0.015) and a biopsy Gleason score of > or =7 (HR: 4.500, 95% CI 1.419-14.274, P=0.011) were independent preoperative predictors of BCR. The presence of PSMA mRNA in peripheral blood can be used to predict BCR after radical prostatectomy.
