Effects of Polygalae Radix on Apomorphine-Induced Stereotyped Behaviors in Mice.
- Author:
In Won CHUNG
1
;
Won Keun OH
;
Sie Kyeong KIM
;
Jong Seog AHN
;
Hyun Sun LEE
;
Chul Jin SHIN
;
Joo Bae PARK
;
Yong Sik KIM
Author Information
1. Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Polygalae radix;
Apomorphine;
Mouse;
Stereotyped behaviors
- MeSH:
Animals;
Apomorphine;
Central Nervous System;
Dopamine;
Haloperidol;
Mice*;
Models, Animal;
Plants;
Polygala*;
Psychopharmacology;
Psychotic Disorders;
Stereotyped Behavior*
- From:Journal of Korean Neuropsychiatric Association
1998;37(6):1317-1324
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was to investigate in vivo activities of Polygalae Radix, a natural plant including active components having affinities to central nervous system receptors, using an animal model for psychotic disorders in terms of behavioral psychopharmacology. METHODS: The extracts of Polygalae Radix in two concentrations of 5.0mg/g and 0..5mg/g were administered to mice in order to explore the suppression of apomorphine-induced stereotyped behaviors visually and to compare with the effects of haloperidol and control. 10 mice were tested in each groups. RESULTS: The capacities of suppressing the apomorphine-induced stereotyped behaviors were observed in decreasing order of haloperidol, Polygalae Radix 5.0mg/g, Polygalae Radix 0..5mg/g and control. The extracts of Polygalae Radix in both concentrations suppressed apomorphine- induced stereotyped behaviors significantly, and Polygalae Radix 5.0mg/g was as potent as haloperidol. CONCLUSION: This suggests that Polygalae Radix contain some effective ingredients to influence the central dopamine pathway in vivo. The identification of the chemical structures and the exploration of the biochemical and pharmacological characteristics of active components are to be required through further studies.
