Two Cases of Castlema's Disease in Childern.
- Author:
Eun Ah KIM
1
;
Chong Guk LEE
;
Han Sung KIM
Author Information
1. Department of Pediatrics, College of Medicine, Inje University, Ilsan Paik Hospital, Korea. chonglee@ilsanpaik.ac.kr
- Publication Type:Case Report
- Keywords:
Castleman's disease
- MeSH:
Anemia;
Blood Sedimentation;
Fatal Outcome;
Follow-Up Studies;
Giant Lymph Node Hyperplasia;
Hypergammaglobulinemia;
Hypoalbuminemia;
Korea;
Lymph Nodes;
Lymphoproliferative Disorders;
Prednisone;
Prognosis;
Recurrence
- From:Journal of the Korean Pediatric Society
2003;46(2):203-206
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutional symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone and other immunosuppressor drugs. The prognosis of the multicentric form is worse than the localized form since malignancies and severe infections may lead to a rapidly fatal outcome. Castleman's disease has been rarely reported at pediatric age in Korea. We experienced two cases of Castleman's disease detected at 3 and 5 years of age. They were presented with painless enlargement of submandibulars and axillary lymph nodes but had no associated symptoms. The lesions were excised and diagnosed as Castleman's disease, and no recurrence was noted during follow-up periods.
