Effects of Antimetabolites on Proliferation of Rabbit Retinal Pigment Epithelial Cells.
- Author:
Ho Kyum KIM
1
;
Hyung Woo KWAK
;
Jae Myung KIM
Author Information
1. Department of Opthalmology, College of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Antimetabolites;
ID50;
Proliferative Vitreoretinopathy
- MeSH:
Antimetabolites*;
Daunorubicin;
Epithelial Cells*;
Fluorouracil;
Mitomycin;
Retinaldehyde*;
Vitreoretinopathy, Proliferative
- From:Journal of the Korean Ophthalmological Society
1996;37(4):602-607
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
