Low-dose and High-dose of Mitomycin-C in Trabeculectomy.
- Author:
Jae Jun LEE
1
;
Ki Ho PARK
;
Dong Ho YOUN
Author Information
1. Department of Ophthalmology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Complete success;
Hypotony;
Mitomycin-C;
Trabeculectomy
- MeSH:
Blister;
Longevity;
Mitomycin*;
Trabeculectomy*
- From:Journal of the Korean Ophthalmological Society
1996;37(4):622-627
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study is to compare the effects of three different concentrations of mitomycin-C(MMC) as an adjunct therapy to trabeculectomy. We reviewed 26 patients(36 eyes) who underwent trabeculectomy in which MMC was applied intraoperatively. The application time was 5 minute, and concentration of MMC was 0.1mg/ml(n=10), 0.2mg/ml(n=17) and 0.41mg/ml(n=9) respectively. The mean IOP at postoperative 3 months was significantly lower in 0.4mg/ml group (10.4 +/- 5.5mmHg) than in the 0.2mg/ml group(16.1 +/- 4.7mmHg)(p<0.05). There was no statistical difference among the three groups in the success rate regardless of medication, the size and longevity of bleb. The postoperative hypotony(2 eyes) was noted in the 0.4mg/ml group. In conclusions, It is desirable to use the lowest concentration of MMC that will facilitate bleb formation.
