Multiple Gastrointestinal Drug Induced Ulcers Associated with Aspirin and Non-steroidal Anti-inflammatory Drugs: A Case Report and Review of the Literature.
- Author:
Hyun Jin KIM
1
;
Woo Chul CHUNG
;
Kang Moon LEE
;
Chang Nyol PAIK
;
Seung Hye JUNG
;
Jin Dong KIM
;
Sung Hoon JUNG
;
Jae Wuk KWAK
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. jwchulkr@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Aspirin;
Non-steroidal anti-inflammatory drug;
Colon ulcer
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
Aspirin;
Colon;
Colonoscopy;
Consensus;
Humans;
Korea;
Peptic Ulcer;
Prostaglandin-Endoperoxide Synthases;
Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
2009;39(6):379-383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed drugs, and they are known to be responsible for many cases of gastroduodenal ulcerations by inhibiting prostaglandin synthesis via blocking the cyclo-oxygenase production. Colonic side effects of these drugs are rare, but they are increasingly being reported to be due to the popularization of colonoscopy and the new formulations of drugs such as enteric coated pills or slow release pills. There is currently no consensus for making the clinical diagnosis and administering the proper therapy for drug-induced colonopathy in Korea. We experienced the patient who had multiple colonic ulcers after ingesting large amounts of aspirin and NSAIDs. In near future, we hope to determine the clinical and endoscopic features of drug associated colon injury.
