A case of flutamide-induced acute cholestatic hepatitis: a case report.
10.3349/ymj.1996.37.3.225
- Author:
Hong Woo LEE
1
;
Jun Pyo CHUNG
;
Kwi Soon LEE
;
Kyung Chul KIM
;
Kwan Sik LEE
;
Chae Yoon CHON
;
In Suh PARK
;
Ho Geun KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Flutamide;
cholestatic hepatitis;
prostatic cancer
- MeSH:
Acute Disease;
Aged;
Androgen Antagonists/*adverse effects;
Case Report;
Cholestasis/*chemically induced;
Flutamide/*adverse effects;
Hepatitis, Toxic/*etiology;
Human;
Male
- From:Yonsei Medical Journal
1996;37(3):225-229
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flutamide, an oral nonsteroidal, antiandrogenic, anilid compound which inhibits the uptake and binding of androgens to nuclear receptors in the prostate, is used with or without LH-RH analogues for treatment of patients with metastatic carcinoma of the prostate. Clinically significant hepatotoxicities such as toxic hepatitis, cholestatic hepatitis, hepatic failure, and even death have rarely been reported in the English literature, but no case has been reported in Korea. A 75-year-old man with metastatic carcinoma of the prostate had taken flutamide (750 mg/day) for 7 months and suddenly developed jaundice and general weakness. The findings of blood chemistries were compatible with cholestatic hepatitis, but ultrasonography, viral marker and auto-antibody studies did not reveal any attributable causes. Histologic examination of a sono-guided liver biopsy only disclosed centrilobular cholestasis, nuclear glycogenosis and mild sinusoidal lymphocytic infiltration. Discontinuation of flutamide resulted in an almost full recovery of the patient's liver function in 2 months. We, herein, report a case of flutamide-induced acute choestatic hepatitis with a brief review of the literature.
