Association of Polymorphisms in Monocyte Chemoattractant Protein-1 Promoter with Diabetic Kidney Failure in Korean Patients with Type 2 Diabetes Mellitus.
10.3346/jkms.2007.22.5.810
- Author:
Ju Young MOON
1
;
Laeik JEONG
;
Sangho LEE
;
Kyunghwan JEONG
;
Taewon LEE
;
Chun Gyoo IHM
;
Jungho SUH
;
Junghee KIM
;
Yoo Yeon JUNG
;
Joo Ho CHUNG
Author Information
1. Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea. rulale@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Diabetic Nephropathies;
Chemokine CCL2;
Polymorphism
- MeSH:
Adult;
Aged;
Alleles;
Chemokine CCL2/*metabolism;
Diabetes Mellitus, Type 2/ethnology/*genetics/*metabolism;
Diabetic Nephropathies/ethnology/*genetics/*metabolism;
Female;
Genotype;
Humans;
Kidney Failure;
Korea;
Male;
Middle Aged;
*Polymorphism, Genetic;
*Promoter Regions, Genetic;
Risk Factors
- From:Journal of Korean Medical Science
2007;22(5):810-814
- CountryRepublic of Korea
- Language:English
-
Abstract:
Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the progression of diabetic nephropathy. We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230). The overall genotypic distribution of -2518 A/G in the MCP-1 gene was not different in patients with type 2 DM compared to healthy controls. Although the genotype was not significantly different between the patients with kidney failure and the diabetic control (p=0.07), the A allele was more frequent in patients with kidney failure than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 1.07-3.18). In logistic regression analysis, carriage of A allele retained a significant association with diabetic kidney failure. Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM.
