Epstein-Barr Virus, Beta-Catenin, and E-cadherin in Gastric Carcinomas.
10.3346/jkms.2007.22.5.855
- Author:
In Mok JUNG
1
;
Jung Kee CHUNG
;
Young A KIM
;
Je Eun KIM
;
Seung Chul HEO
;
Young Joon AHN
;
Ki Tae HWANG
;
Byeong Gwan KIM
;
Kook Lae LEE
;
Chul Woo KIM
;
Woo Ho KIM
;
Mee Soo CHANG
Author Information
1. Department of Surgery, Seoul National University Boramae Hospital, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Stomach Neoplasms;
Herpesvirus 4, Human;
Beta Catenin;
Cadherins;
Prognosis
- MeSH:
Adult;
Aged;
Cadherins/*metabolism;
Carcinoma/*metabolism/*virology;
Cell Nucleus/metabolism;
Female;
*Gene Expression Regulation, Neoplastic;
*Gene Expression Regulation, Viral;
Herpesvirus 4, Human/*metabolism;
Humans;
Immunohistochemistry/methods;
In Situ Hybridization;
Male;
Middle Aged;
NF-kappa B/metabolism;
Prognosis;
Stomach Neoplasms/*metabolism/*virology;
beta Catenin/*metabolism
- From:Journal of Korean Medical Science
2007;22(5):855-861
- CountryRepublic of Korea
- Language:English
-
Abstract:
Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relationship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, betacatenin, and E-cadherin immunohistochemistry, and clinicophatological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplamic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with betacatenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient's survival (p<0.05). In conclusion, betacatenin activation through nuclear accumulation hardly occurred in EBV-infected gastric carcinomas. The combined immunoexpression pattern of beta-catenin and E-cadherin can be used as a prognostic marker in gastric carcinomas.
