Increased sFlt-1 to PlGF Ratio in Women Who Subsequently Develop Preeclampsia.
10.3346/jkms.2007.22.5.873
- Author:
Shin Young KIM
1
;
Hyun Mee RYU
;
Jae Hyug YANG
;
Moon Young KIM
;
Jung Yeol HAN
;
Joo Oh KIM
;
Jin Hoon CHUNG
;
So Yeon PARK
;
Moon Hee LEE
;
Do Jin KIM
Author Information
1. Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pre-Eclampsia;
Fms-like Tyrosine Kinase 1;
Placental Growth Factor;
Biological Markers
- MeSH:
Adult;
Biological Markers/metabolism;
Case-Control Studies;
Female;
Humans;
Immunoassay;
Middle Aged;
Placenta/metabolism;
Pre-Eclampsia/*diagnosis/*metabolism;
Pregnancy;
Pregnancy Proteins/*biosynthesis;
Pregnancy Trimester, Second;
ROC Curve;
Sensitivity and Specificity;
Vascular Endothelial Growth Factor Receptor-1/*biosynthesis
- From:Journal of Korean Medical Science
2007;22(5):873-877
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels of sFlt-1 and PlGF in the preeclamptic (n=46) and normal pregnant women (n=100). The maternal plasma levels of sFlt-1 and PlGF were measured by enzyme-linked immunosorbent assay. The sFlt-1 levels were significantly higher in the preeclamptic women than in normal controls (p<0.001), while the PlGF levels were significantly lower (p<0.001). In normal controls, sFlt-1 levels were positively correlated (r=0.27, p=0.008), whereas, in the preeclamptic women, those were negatively correlated with the PlGF levels (r=-0.423, p=0.005). Furthermore, the log[sFlt-1/PlGF] ratio was significantly higher in the preeclamptic women than in normal controls (p<0.001). The receiver operating characteristic curve revealed a specificity of 78% with a diagnostic sensitivity of 80.4%; the optimal cut-off value of the log[sFlt-1/PlGF] ratio was 1.4 (95% CI 0.756-0.910, p<0.001). Preeclampsia showed a strong association with increased levels of sFlt-1 and decreased levels of PlGF in the second trimester maternal plasma. Accordingly, the sFlt-1/PlGF ratio may provide early prediction of subsequent development of preeclampsia.
