Acute Marchiafava-Bignami Disease with Widespread Callosal and Cortical Lesions.
10.3346/jkms.2007.22.5.908
- Author:
Min Jeong KIM
1
;
Jong Kuk KIM
;
Bong Goo YOO
;
Kwang Soo KIM
;
Young Duk JO
Author Information
1. Department of Neurology, Kosin University College of Medicine, Busan, Korea. ybgne@ns.kosinmed.or.kr
- Publication Type:Case Report
- Keywords:
Alcohol-Related Disorders;
Cerebral Cortex;
Diffusion Magnetic Resonance Imaging
- MeSH:
Alcoholism/complications;
Brain/pathology;
Cerebral Cortex/*pathology;
Corpus Callosum/*pathology;
Demyelinating Diseases/pathology;
Diffusion Magnetic Resonance Imaging/methods;
Humans;
Male;
Marchiafava-Bignami Disease/*diagnosis/*pathology/*therapy;
Middle Aged;
Necrosis/pathology;
Neurodegenerative Diseases/pathology;
Optic Chiasm/pathology;
Seizures;
Time Factors;
Treatment Outcome;
Vitamin B Complex/therapeutic use
- From:Journal of Korean Medical Science
2007;22(5):908-911
- CountryRepublic of Korea
- Language:English
-
Abstract:
Marchiafava-Bignami disease (MBD) is a rare alcohol-related disorder that results in progressive demyelination and necrosis of the corpus callosum. The process may extend to the optic chiasm and tracts, cerebellar peduncle, subcortical resion, neighboring white matter, and rarely, cortical gray matter. We report a case of MBD in which fluid-attenuated inversion recovery and diffusion magnetic resonance imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex in addition to the callosal lesions.
