A Case of Cowden Syndrome.
- Author:
Won Kyu HONG
1
;
Hee Jin SONG
;
Hyeon Sook LEE
;
Jong Rock LEE
;
Jeong Hyun SHIN
;
Gwang Seong CHOI
Author Information
1. Department of Dermatology, Inha University School of Medicine, Korea. garden@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Atopic dermatitis;
Cowden
- MeSH:
Adult;
Biopsy;
Colonoscopy;
Dermatitis, Atopic;
Gastrointestinal Tract;
Hamartoma;
Hamartoma Syndrome, Multiple*;
Humans;
Keratosis;
Papilloma;
Skin
- From:Korean Journal of Dermatology
2007;45(8):829-831
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cowden syndrome is a rare autosomal dominant disorder characterized by mucocutaneous alterations including multiple facial trichilemmomas, oral mucosal papillomatosis, and acral keratoses. Extracutaneous lesions include polyposis of the gastrointestinal tract, and other multiple hamartoma of the internal organs. A 39 year-old man presented with multiple verruca-like papules and lichenified patches on the face, one year ago. He had been treated for atopic dermatitis for more than 10 years. Although he had been treated in accordance with atopic dermatitis for 1 year, his skin lesions had not improved, so a skin biopsy was performed. The skin biopsy specimen revealed the typical finding of trichilemmoma. Colonoscopy diagnosed diffuse colorectal polyposis. The clinical and hisopathologic findings were consistent with Cowden syndrome. We, herein, report a case of Cowden syndrome with atopic dermatitis.
