A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin.
10.3904/kjm.2014.87.4.491
- Author:
Jun Jae KIM
1
;
Hyun Jung KIM
;
Sang Hyun KIM
;
Won Do PARK
Author Information
1. Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. shkim@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Ciprofloxacin;
Acute kidney injury;
Acute tubular necrosis;
Hearing loss
- MeSH:
Acute Kidney Injury;
Administration, Intravenous*;
Adult;
Biopsy;
Ciprofloxacin*;
Creatinine;
Female;
Gastroenteritis;
Hearing;
Hearing Loss*;
Humans;
Korea;
Necrosis*;
Nephritis, Interstitial;
Renal Dialysis
- From:Korean Journal of Medicine
2014;87(4):491-495
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea.
