A Case of Myasthenia Gravis after Allogeneic Bone Marrow Transplantation.
- Author:
Joong Seok KIM
1
;
Dong Won YANG
;
Seok Beum KO
;
Soung Kyeong PARK
;
Beum Saeng KIM
Author Information
1. Department of Neurology, College of Medicine, The Catholic University of Korea.
- Publication Type:Case Report
- Keywords:
Bone marrow transplantation;
Acute graft-versus-host disease;
Myasthenia gravis
- MeSH:
Acetylcholine;
Adult;
Autoantibodies;
Autoimmune Diseases;
Autoimmunity;
Bone Marrow Transplantation*;
Bone Marrow*;
Female;
Graft vs Host Disease;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Myasthenia Gravis*;
Pyridostigmine Bromide;
Siblings;
Steroids
- From:Journal of the Korean Neurological Association
2001;19(1):60-61
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 38-year-old woman, affected by chronic myeloid leukemia, received a BMT from his HLA identical brother. A mild acute graft-versus-host disease (GVHD) developed during the first month after the BMT. A typical clinical and electrophysiological feature of myasthenia gravis (MG) developed 3 months after the BMT requiring medication with pyridostigmine and steroids. Laboratory findings including acetylcholine receptor antibody and other autoantibodies were negative. MG is a well-characterized autoimmune disease which, on rare occasions, is also diagnosed as chronic GVHD after BMT. We report a first case of MG during an acute GVHD period. Since the patient had a myasthenic symptom during an acute GVHD period and no evidence of antibody mediated autoimmunity, this is likely to be an immune complication of acute GVHD. (J Korean Neurol Assoc 19(1):60~61, 2001
