The Clinical Usefulness of 18F-FDG PET/CT for the Evaluation of Lymph Node Metastasis in Periorbital Malignancies.
- Author:
Chung Hwan BAEK
1
;
Man Ki CHUNG
;
Han Sin JEONG
;
Young Ik SON
;
Jeesun CHOI
;
Yoon Duck KIM
;
Joon Young CHOI
;
Hyung Jin KIM
;
Young Hyeh KO
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: 18F-FDG; PET/CT; Computed tomography (CT) scans; Lymphatic Metastasis; Eyelid Neoplasm
- MeSH: Adult; Aged; Contrast Media; Eye Neoplasms/pathology/*secondary; Eyelid Neoplasms/pathology/secondary; Female; Fluorodeoxyglucose F18/*diagnostic use; Humans; Iohexol/analogs & derivatives/diagnostic use; Lacrimal Apparatus Diseases/pathology; Lymphatic Metastasis/diagnosis; Male; Middle Aged; *Positron-Emission Tomography; Radiopharmaceuticals/*diagnostic use; Sensitivity and Specificity; *Tomography, X-Ray Computed/methods
- From:Korean Journal of Radiology 2009;10(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The aim of this study was to assess the clinical role of 18F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies, compared with CT alone. MATERIALS AND METHODS: We analyzed eighteen PET/CT and CT scans in 15 patients with biopsy-proven periorbital malignancies. We compared the diagnostic capabilities of PET/CT and CT with regard to nodal metastasis by level-by-level analysis and by N staging prediction. The reference standards were surgical pathology (n = 7) from dissected lymph node specimens and the results from radiological follow-up (n = 11, mean 20.5 months; range 10-52 months). Moreover, any changes in patient care as prompted by PET/CT were recorded and compared with treatment planning for CT alone. RESULTS: PET/CT had a sensitivity of 100%, while CT had a sensitivity of 57% (p = 0.03) for nodal metastasis by level-by-level analysis. PET/CT had a specificity of 97%, positive predictive value of 93%, negative predictive value of 100%, and diagnostic accuracy of 98%, while the CT values for these same parameters were 97%, 89%, 82%, and 84%, respectively. PET/CT correctly predicted N staging with an accuracy of 100%, while CT was only 83% accurate (p = 0.01). Regarding the impact on patient care, the extent of surgery for regional lymph nodes and the treatment decision were modified by PET/CT in 39% of patients. CONCLUSION: PET/CT could provide useful information in the management of regional lymph node metastases in patients with periorbital malignancies.
