The effects of inspiratory to expiratory ratio on ventilation and oxygenation during high frequency partial liquid ventilation in a rabbit model of acute lung injury.
10.4097/kjae.2009.57.2.203
- Author:
Myung Hee SONG
1
;
In Cheol CHOI
;
Kyung Don HAHM
;
Yong Bo JEONG
;
Kyu Taek CHOI
Author Information
1. Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea. icchoi@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Acute lung injury;
Expiratory ratio;
Gas exchange;
High frequency jet ventilation;
Inspiratory;
Partial liquid ventilation;
Perfluorocarbon
- MeSH:
Acute Lung Injury;
Cardiac Output;
Hemodynamics;
High-Frequency Jet Ventilation;
High-Frequency Ventilation;
Liquid Ventilation;
Oxygen;
Rabbits;
Therapeutic Irrigation;
Ventilation
- From:Korean Journal of Anesthesiology
2009;57(2):203-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We examined the effects of varying inspiratory to expiratory (I : E) ratio on gas exchange and hemodynamics during high frequency partial liquid ventilation (HFPLV), a combination of high frequency ventilation (HFV) and partial liquid ventilation (PLV), in a rabbit model of acute lung injury. METHODS: Twelve rabbits treated with repeated saline lavage were divided into two groups. In the HFPL group (n = 6), 6 ml/kg of perfluorodecaline was administered through the endotracheal tube. Rabbits in this group and in the HFJ group (n = 6) were treated with high frequency jet ventilation (HFJV) at I : E ratios of 1 : 1, 1 : 2, and 1 : 3 for 15 minutes, and arterial blood gas, mixed venous blood gas and hemodynamic parameters were measured. RESULTS: We observed no significant respiratory and hemodynamic differences between the two groups. At an I : E ratio of 1 : 1, the PaO2 was significantly higher, and the shunt rate and PaCO2 were significantly lower in both groups, compared with I : E ratios of 1 : 2 and 1 : 3. Cardiac output at the 1 : 3 I : E ratio was significantly higher than at 1 : 1. CONCLUSIONS: These findings indicate that, in this model, a 1 : 1 I : E ratio was superior for oxygenation and ventilation than I : E ratios of 1 : 2 or 1 : 3, while having no detrimental effects on hemodynamics.
