Acute liver injury after sevoflurane anesthesia: A case report.
10.4097/kjae.2009.57.2.221
- Author:
Jong Taek PARK
1
;
Young Bok LEE
;
Jong Soo KIM
;
Hoon RYU
;
Hyun Kyo LIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. hyunkyolim@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Hepatotoxicity;
Sevoflurane
- MeSH:
Anesthesia;
Female;
Halothane;
Humans;
Isoflurane;
Liver;
Methyl Ethers;
Propanols;
Proteins
- From:Korean Journal of Anesthesiology
2009;57(2):221-224
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Halothane, isoflurane and desflurane are metabolized to hepatotoxic trifluoroacetyl proteins. But sevoflurane is metabolized to hexafluoroisopropanol. Hexafluoroisopropanol has a low binding affinity for liver protein and is therefore rapidly converted to glucuronidate that are excreted in the urine. Thus sevoflurane has been considered to have a very low potential for hepatotoxicity. We report a case of a 67 years old woman who developed acute hepatic dysfunction after sevoflurane anesthesia.
