Was a hypertensive crisis in a patient with pheochromocytoma caused by rocuronium?: A case report.
10.4097/kjae.2009.57.2.249
- Author:
Cheol Won JEONG
1
;
Hyung Gon LEE
;
Woong Mo KIM
;
Seung Heon SHIN
;
Hong Beom BAE
Author Information
1. Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea. nextphil2@freechal.com
- Publication Type:Case Report
- Keywords:
Catecholamine;
Hypertensive crisis;
Pheochoromocytoma;
Rocuronium
- MeSH:
Adrenal Medulla;
Androstanols;
Anesthesia, General;
Anesthetics;
Arterial Pressure;
Atracurium;
Catecholamines;
Humans;
Norepinephrine;
Pancuronium;
Pheochromocytoma;
Plasma;
Sympathetic Nervous System
- From:Korean Journal of Anesthesiology
2009;57(2):249-253
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pheochromocytoma is an uncommon tumor that originates in the adrenal medulla or in other paraganglia of the sympathetic nervous system. If a hypertensive crisis occurs during general anesthesia in incidental or untreated pheochromocytoma, it is a life-threatening event with a mortality rate of about 80%. Anesthetic drugs such as pancuronium, atracurium, and metoclopromide can exacerbate the potentially lethal cardiovascular effects of catecholamines. We report a case of a patient with pheochromocytoma who display abrupt increases in systolic arterial pressure and plasma norepinephrine following rocuronium administration. This case indicates the possible involvement of elevated sympathetic nervous system to a catecholamine crisis triggered by rocuronium in pheochromocytoma.
