Change of serum ghrelin concentration according to severity of hepatosteatosis.
- Author:
Tae Woo YOO
1
;
Yong Kyun CHO
;
Mun Su KANG
;
Se Yong OH
;
Jung Ho PARK
;
Hong Joo KIM
;
Dong Il PARK
;
Chong Il SOHN
;
Woo Kyu JEON
;
Byung Ik KIM
;
Chan Hee JUNG
;
Eun Jung RHEE
;
Won Young LEE
;
Ki Won OH
;
Sun Woo KIM
;
Eun Joo YUN
;
Eun Sook OH
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. choyk2004.cho@samsung.com
- Publication Type:Original Article
- Keywords:
Ghrelin;
Fatty liver;
Insulin resistance
- MeSH:
Adult;
Certification;
Fatty Liver;
Ghrelin*;
Hip;
Humans;
Insulin Resistance;
Linear Models;
Liver;
Male
- From:Korean Journal of Medicine
2006;71(1):45-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recently, ghrelin has been reported to be associated with insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is a condition in which insulin resistance relatively plays a pivotal role. The aim of this study was to evaluate the change of serum ghrelin concentration according to severity of hepatosteatosis. METHODS: Sixty five apparently normal male adults who underwent health screen examinations were classified into three groups, Group I: normal (27 subjects), Group II: mild (24 subjects) and Group III: moderate to severe fatty liver (14 subjects), according to ultrasonographic findings of liver. We analyzed the association between serum ghrelin concentration and severity of hepatosteatosis by ANOVA test. And the independent correlation between serum ghrelin concentration and insulin resistance related factors, HOMA (homeostatic model assessment), BMI (body mass index), WC (waist circumference), HC (hip circumference), WHR (waist to hip circumference ratio) were analyzed by multiple linear regression analysis. RESULTS: Serum ghrelin concentration tended to decrease according to severity of hepatosteatosis (Group I: 230.9+/-94.3, Group II: 195.2+/-97.2, Group III: 164.3+/-71.4 pmol/L). But this was statistically insignificant (p=0.081). The independent correlation between serum ghrelin concentration and insulin resistance related factors were not observed. CONCLUSIONS: Our study did not prove the correlation between insulin resistance related factors and serum ghrelin concentration in NAFLD according to severity of hepatosteatosis. However, we found a tendency to decrease serum ghrelin concentration according to severity of hepatosteatosis. So, further studies are required for certification these correlations.
