Clinical Islet Transplantation: Where Do We Stand on?.
- Author:
Jae Berm PARK
1
;
Sung Joo KIM
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kmhyj111@hotmail.com
- Publication Type:Review ; Clinical Trial
- Keywords:
Pancreas islet cell transplantation;
Type I diabetes mellitus
- MeSH:
Diabetes Mellitus;
Hope;
Islets of Langerhans Transplantation*
- From:The Journal of the Korean Society for Transplantation
2007;21(2):196-202
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Islet transplantation had been suggested as a potential treatment modality for type I diabetes mellitus for the last two decades. The methods for the islet isolation and purification were developed. In 2000, the excellent clinical outcomes from the Edmonton group were reported. And various basic researches were performed for the elucidation of the mechanism of initial islet loss. Although the Edmonton protocol, which had initially raised hopes that all the technical and immunologic problems would be solved, recently revealed as a limited success within the selective cases and short-term follow-up, these inspirations led us to the subsequent clinical or basic research of islet transplantation. As a result, many clinical trials and studies have been attempted for the establishment of the optimal immune suppression regimen, the prevention from islet loss in the process of isolation, and the improvement of the intraportal engraftment. This article reviews the history and the recent progress and possible strategies for the clinical islet transplantation.
