A Case of Severe Hypertensive Pulmonary Edema Associated with Neuroblastoma during Chemotherapy.
- Author:
Hee Suk CHO
1
;
Hwang Min KIM
;
Seok Won PARK
;
Jong Soo KIM
;
Yoon Mi KIM
;
Kwang Kil LEE
Author Information
1. Department of Pediatrics and Pathology, College of Medicine, Yonsei University Wonju, Wonju, Korea.
- Publication Type:Case Report
- Keywords:
Neuroblastoma;
Hypertension;
Pulmonary edema;
Catecholamine;
Chemotherapy;
Differentiation
- MeSH:
Adrenergic alpha-Antagonists;
Aorta;
Catecholamines;
Child;
Drug Therapy*;
Ganglioneuroblastoma;
Heart Failure;
Humans;
Hypertension;
Male;
Neuroblastoma*;
Pulmonary Edema*
- From:Journal of the Korean Pediatric Society
2000;43(4):573-577
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors report a 7-year-old boy with neuroblastoma complicated by severe hypertension and pulmonary edema. Abdominal computed tomographic scan revealed a huge mass surrounding the aorta. After administration of cancer treatment, there was a marked increase in serum catecholamines level and hypertension, which resulted in pulmonary edema and heart failure. Alpha adrenergic blocking agents (prazocin, terazocin) were administrated, successfully controlling the hypertension. The tumor differentiated to ganglioneuroblastoma after chemotherapy. The catecholamine production of the residual neuroblastoma must have increased because the treatment induced differentiation. It is important to watch for the development of hypertension during the treatment of neuroblastoma.
