Immunohistochemical Staining for Type II Collagen in Regenerated Cartilage after Microfracture Surgery.
- Author:
Dae Kyung BAE
1
;
Ki Woong CHUNG
;
Jin Moon KIM
;
Chang Hyeok KWON
;
Yong Koo PARK
Author Information
1. Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Knee;
Osteoarthritis;
Microfracture;
Type II collagen;
immunohistochemical;
staining
- MeSH:
Biopsy;
Cartilage*;
Cartilage, Articular;
Collagen;
Collagen Type II*;
Female;
Humans;
Joints;
Knee;
Osteoarthritis;
Prognosis
- From:Journal of Korean Orthopaedic Research Society
2000;3(1):1-4
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study is to identify nature of regenerated articular cartilage after microfracture surgery. MATERIALS AND METHODS: From Oct. 1997 to Nov. 1998, 40 knees were treated for osteoarthritis by arthroscopic microfracture technique. In the 18 knees, during the second arthroscopic procedure, biopsy specimens extending to the subchondral bone were taken and immunohistochemical staining was done to identify type of collagen. One patient was man and 17 patients were women. Average age of the patients were 58 years (range, 40-75 years). RESULTS: Type II collagen in articular cartilage appeared to be brown color with this staining. Degree of staining were +3 in 4 knees(22%), +2 in 2 knees(11%), +1 in 7 knees(39%) and trace in 5 knees(28%). CONCLUSION: Microfracture surgery restores the function of the joint by forming predominantly hyaline-like cartilage containing type II collagen. As analyzing amounts of type II collagen with an immunohistochemical staining in regenerated cartilage, we can presume the prognosis of regenerated cartilage tissue after microfracture surgery.
