Occupational asthma caused by several kinds of herb materials.
- Author:
Soo Keol LEE
1
;
Jung Hee SEO
;
Hyeon Kyeong CHO
;
Sun Sin KIM
;
Dong Ho NAHM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology Ajou University, School of Medicine, Suwon, Korea.
- Publication Type:Retracted Publication ; Case Report
- Keywords:
Herbs;
Asthma;
Occupational diseases;
IgE
- MeSH:
Allergens;
Angelica;
Antibodies;
Asthma;
Asthma, Occupational*;
Bronchoconstriction;
Cnidium;
Electrophoresis;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hypersensitivity;
Immunoglobulin E;
Occupational Diseases;
Pharmacists;
Pharmacy;
Pinellia;
Rhinitis;
Sodium
- From:Korean Journal of Medicine
2000;59(2):213-219
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There have been a few cases of occupational allergy caused by herb materials. In this study, we report a case of occupational asthma and rhinitis sensitized by six kinds of herb materials-Ostericum (Kangwhal), Angelica (Danggui), Cnidium (Chunkung), Pinellia (Banha), Zingerber (Kunkang) and Discoreae (Sanyak) in a pharmacist working at a pharmacy. The patient had shown negative responses to 80 common inhalant and food allergens, but strong positive responses to six herb material extracts, Kangwhal, Danggui, Chunkung, Banha, Kunkang and Sanyak, were noted on skin-prick test. Bronchoprovocation test showed a dual asthmatic response to Danggui extract. Serum specific IgE antibodies to Chunkung, Banha and Sanyak were detected by enzyme-linked immunosorbent assay (ELISA) with no specific IgE binding to Kangwhal, Danggui and Kunkang extracts. In order to further characterize the allergic components of these three extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were performed. One IgE binding components (60 kDa) were detected within Chunkung extract, two (10, 25 kDa) in Banha and four (33, 34, 65, 98 kDa) in Sanyak. It is suggested that Chunkung, Banha and Sanyak may induce IgE-mediated bronchoconstriction in an exposed worker. Further studies are needed to investigate the pathogenic mechanisms induced by Kangwhal, Danggui and Kunkang.
