Gamma interferon modulates epidermal cell proliferation and mixed epidermal cell-lymphocyte reaction.
10.3346/jkms.1987.2.3.151
- Author:
Si Yong KIM
1
;
Won HOUH
Author Information
1. Department of Dermatology, Medical College Catholic University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Epidermal cell (EC);
Gamma-interferon (gamma-IFN) HLA-DR positive kerationocyte (HLA-DR+KC);
Langerhans cell (LC);
Mixed epidermal cell-lymphocyte reaction (MECLR);
Peripheral blood lymphocytes (PBL)
- MeSH:
Adolescent;
Adult;
Cell Division/*drug effects;
Female;
HLA-DR Antigens/*immunology;
Humans;
Interferon-gamma/*pharmacology;
Lymphocytes/cytology/drug effects/*immunology;
Male;
Skin/*cytology/drug effects
- From:Journal of Korean Medical Science
1987;2(3):151-156
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gamma interferon (gamma-IFN), a lymphokine produced by activated T lymphocytes, has a variety of effects on target cell. It induces class II antigens of the major histocompatibility complex not only in immunocompetent cells but also in non-immunocompetent cells. gamma-IFN also can exert, in addition to anti-viral activity, a series of anticellular effects on a variety of cell types. The effects of gamma-IFN on the proliferation of cultured epidermal cell (EC) and induction of HLA-DR antigen expression by EC (HLA-DR+KC) were studied. Furthermore, the immunologic role of HLA-DR+KC in the mixed epidermal cell-lymphocyte reaction (MECLR) was studied. The antiproliferative effect of gamma-IFN on the cultured EC was seen 3 days after treatment of gamma-IFN and the effect was dose-dependent. Number of HLA-DR+KC was increased dose-dependently with treatment of gamma-IFN. In MECLR, HLA-DR+KC had been found to exert stimulatory role on allogenic lymphocytes. However, there was no significant role of HLA-DR+KC on autologous lymphocytes.
