Severe neurologic manifestations in acute intermittent porphyria developed after spine surgery under general anesthesia: a case report.
10.4097/kjae.2014.67.3.217
- Author:
Eun Young PARK
1
;
Yi Seul KIM
;
Kyung Jee LIM
;
Hye Kyoung LEE
;
Soo Kyung LEE
;
Hyun CHOI
;
Mae Hwa KANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Hallym University College of Medicine, Anyang, Korea. drberry@hanmail.net
- Publication Type:Case Report
- Keywords:
Delayed emergence from anesthesia;
General anesthesia;
Guillain-Barre Syndrome;
Porphyrias;
Wernicke encephalopathy
- MeSH:
Abdominal Pain;
Anesthesia;
Anesthesia, General*;
Biosynthetic Pathways;
Delayed Emergence from Anesthesia;
Diagnosis;
Guillain-Barre Syndrome;
Heme;
Humans;
Neurologic Manifestations*;
Porphyria, Acute Intermittent*;
Porphyrias;
Spine*;
Wernicke Encephalopathy
- From:Korean Journal of Anesthesiology
2014;67(3):217-220
- CountryRepublic of Korea
- Language:English
-
Abstract:
Porphyrias are inherited metabolic disorders resulting from a specific enzyme defect in the heme biosynthetic pathway. Porphyrias are induced by various precipitants. Clinical features include abdominal pain, neurologic manifestations, autonomic neuropathy, and mental disturbance. Diagnosis may be delayed because of variable symptoms that mimic other diseases and because of the rarity of of porphyrias. Although most patients with known porphyria can complete anesthesia and surgery safely, undiagnosed porphyric patients are in danger of porphyric crisis due to inadvertent exposure to precipitating drugs and environment. We report a case of a patient who experienced delayed emergence with neurological disturbance after general anesthesia, ultimately diagnosed as acute intermittent porphyria.
