Clinical Characteristics of Gastroesophageal Reflux Disease with Esophageal Injury in Korean: Focusing on Risk Factors.
10.4166/kjg.2011.57.5.281
- Author:
Seung Jun LEE
1
;
Min Kyu JUNG
;
Sung Kook KIM
;
Byung Ik JANG
;
Si Hyung LEE
;
Kyeong Ok KIM
;
Eun Soo KIM
;
Kwang Bum CHO
;
Kyung Sik PARK
;
Eun Young KIM
;
Jin Tae JUNG
;
Joong Goo KWON
;
Joong Hyun LEE
;
Chang Hun YANG
;
Chang Keun PARK
;
Hyang Eun SEO
;
Seong Woo JEON
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. swjeon@knu.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Gastroesophageal reflux;
Endoscopy;
Alcohol drinking;
Antacids;
Signs and symptoms
- MeSH:
Adolescent;
Adult;
Aged;
Alcohol Drinking;
Antacids/therapeutic use;
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use;
Aspirin/therapeutic use;
Barrett Esophagus/complications/diagnosis;
Body Mass Index;
Coffee;
Endoscopy, Gastrointestinal;
Esophagitis, Peptic/complications/*diagnosis;
Female;
Gastroesophageal Reflux/complications/*diagnosis;
Humans;
Logistic Models;
Male;
Middle Aged;
Questionnaires;
Republic of Korea;
Risk Factors;
Severity of Illness Index;
Sex Factors;
Waist Circumference
- From:The Korean Journal of Gastroenterology
2011;57(5):281-287
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Recent studies suggest that the prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea. However, studies on risk factors for GERD have yielded inconsistent results. The aims of this study were to compare clinical features between symptomatic syndromes without esophageal injury (=non-erosive disease [NED]) and syndromes with esophageal injury (=erosive disease [ED]), and to determine risk factors associated ED. METHODS: A total of 450 subjects who visited gastroenterology clinics of six training hospitals in Daegu from March 2008 to April 2010 were consecutively enrolled. The subjects were asked to complete a questionnaire which inquired about gastroesophageal reflux symptoms. The questionnaire also included questions about smoking, alcohol drinking, consumption of coffee, use of drugs, exercise, and other medical history. The subjects were subdivided into NED and ED groups. RESULTS: The proportion of subjects in each NED and ED group was 172 (38.2%) and 278 (61.8%). Male gender, smoking, alcohol drinking, consumption of coffee, large waist circumference, infrequent medication of antacids, aspirin and NSAIDs, infrequent and mild GERD symptoms were all significantly associated with ED on univariate analysis. Age, hiatal hernia, diabetes mellitus, body mass index, change in weight during 1 year, and number of typical GERD symptoms were not independent risk factors for ED. However, the association between ED and alcohol drinking, infrequent medication of antacids, mild typical GERD symptoms remained as strong risk factors after adjustments on multivariate logistic analysis. CONCLUSIONS: Independent risk factors associated with ED were alcohol drinking, infrequent medication of antacids and mild typical GERD symptoms.
