A Case of Autoimmune Hepatitis Following Acute Hepatitis A.
10.4166/kjg.2011.57.5.315
- Author:
Young Doo KIM
1
;
Kyung Ah KIM
;
Woo Sun ROU
;
June Sung LEE
;
Tae June SONG
;
Won Ki BAE
;
Nam Hoon KIM
Author Information
1. Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. kakim@paik.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Hepatitis A;
Autoimmune hepatitis
- MeSH:
Acute Disease;
Alanine Transaminase/blood;
Antibodies, Antinuclear/analysis;
Aspartate Aminotransferases/blood;
Autoantibodies/analysis;
Azathioprine/therapeutic use;
Female;
Hepatitis A/complications/*drug therapy;
Hepatitis, Autoimmune/*diagnosis/drug therapy/etiology;
Humans;
Hypergammaglobulinemia/diagnosis;
Immunosuppressive Agents/therapeutic use;
Liver/pathology;
Middle Aged;
Prednisolone/therapeutic use
- From:The Korean Journal of Gastroenterology
2011;57(5):315-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pathogenesis of autoimmune hepatitis (AIH) is unclear, but viral infections have been proposed as a potential trigger in patients with genetic predisposition. We report a case of AIH following acute hepatitis A (AHA). A 57-year-old woman presented with fatigue and pitting edema for last 3 months. She had been diagnosed as an AHA 15 months ago based on clinical features, biochemical tests and positive HAV IgM antibody at a local clinic. Her biochemical tests was normalized one month after AHA diagnosis, but the serum levels of aminotransferase started to rise four months after AHA diagnosis. Antinuclear antibody was positive at a titer of 1:40, and anti-smooth muscle antibody was also positive. Hypergammaglobulinemia and liver pathology were typical for AIH. The patients had a score of 17 according to the International Autoimmune Hepatitis Group's system. She was given prednisolone and azathioprine and showed complete response to immunosuppressive therapy. The present case is the first report on AIH triggered by AHA in Korea.
