Effect of Gd-DTPA on Diffusion in Canine Brain with Hyperacute Stroke.
- Author:
Bum Soo KIM
1
;
So Lyung JUNG
;
Kyung Sub SHIN
Author Information
1. Department of Radiology, The Catholic University of Korea, Korea. bumrad@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Cerebral infarction;
Gadolinium-DTPA;
Apparent diffusion coefficient
- MeSH:
Animals;
Brain*;
Carotid Artery, Internal;
Cerebral Infarction;
Diffusion*;
Dogs;
Gadolinium DTPA*;
Infarction;
Injections, Intravenous;
Magnetic Resonance Imaging;
Perfusion;
Stroke*
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2002;6(2):158-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of Gd-DTPA on signal intensity of diffusion-weighted magnetic resonance (MR) image and apparent diffuse coefficient (ADC) in dog brain with hyperacute stroke. MATERIALS AND METHODS: Experimental canine model of hyperacute cerebral infarction was made by selective intraarterial embolization with particulate embolic material. Diffusion-weighted MR imaging was performed in five dogs at 1 hour after the embolization of internal carotid artery. After intravenous bolus injection of Gd-DTPA, additional 11 diffusion-weighted MR images were serially obtained from 2 minutes to 90 minutes after injection in each dog. The author evaluated findings of hyperacute cerebral infarction on diffusion-weighted MR imaging, and calculated mean signal intensity and mean ADC in infarcted region and contralateral normal region. Statistical analysis of mean signal intensity, mean ADC and contrast-noise ratio before and after Gd-DTPA injection was performed. RESULTS: Hyperacute cerebral infarction developed in all five dogs on diffusion-weighted MR images obtained 1 hour after embolization. The area of hyperacute infarction had steady increase in signal intensity on diffusion-weighted MR image and decrease in ADC. In normal perfusion area, decrease in signal intensity was observed at 2 minutes the Gd-DTPA injection, whereas ADC did not changed. CONCLUSION: Intravenous injection of Gd-DTPA had no influence on ADC in both hyperacute infarction and normally perfused area, but caused initial transient signal reduction in normally perfused area on diffusion-weighted MR image due to susceptibility effect of Gd-DTPA. It is important to calculate ADC in evaluating the effect of diffusion after injection of Gd-DTPA.
