Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity.
10.3345/kjp.2012.55.9.344
- Author:
Jieun LEE
1
;
Juyoung YOON
;
Jin A LEE
;
Seong Yong LEE
;
Choong Ho SHIN
;
Sei Won YANG
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Obesity;
Melatonin;
6-Sulfatoxymelatonin;
Child
- MeSH:
Body Mass Index;
Body Weight;
Child;
Creatinine;
Fasting;
Ghrelin;
Glucose;
Humans;
Insulin;
Leptin;
Melatonin;
Obesity
- From:Korean Journal of Pediatrics
2012;55(9):344-349
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism. METHODS: A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels. RESULTS: There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages. CONCLUSION: Our results suggest that melatonin production is not reduced consistently in obese girls.
