H rthle Cell Neoplasm of the Thyroid Gland.
- Author:
Jeong Eon LEE
1
;
Tae Seon KIM
;
Young Cheol KIM
;
Dong Young NOH
;
Yeo Kyu YOUN
;
Kuk Jin CHOE
;
Seung Keun OH
Author Information
1. Department of Surgery, Seoul National University College of Medicine.
- Publication Type:Original Article
- Keywords:
Thyroid tumor;
H rthle cell neoplasm;
H rthle cell carcinoma
- MeSH:
Adenoma;
Aged;
Biopsy, Fine-Needle;
Carcinoma, Papillary;
Female;
Follow-Up Studies;
Humans;
Hyperthyroidism;
Incidence;
Korea;
Lymph Node Excision;
Male;
Neck;
Prognosis;
Rare Diseases;
Recurrence;
Retrospective Studies;
Seoul;
Sex Ratio;
Thyroid Gland*;
Thyroidectomy
- From:Journal of the Korean Surgical Society
2000;58(5):629-634
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: H rthle cell neoplasm of the thyroid gland is a rare disease. The reported cases in Korea are not so many; thus, there has been a lack of common therapeutic and prognostic guidance. METHODS: The cases of 15 patients with a H rthle cell neoplasm of the thyroid gland, hospitalized at Seoul National University Hospital from Nov. 1981 to Feb. 1998, were retrospectively reviewed. RESULTS: There were 4 males and 11 females. The ages varied from 23 to 69 years old (mean: 46.3 years old). Among them, 13 had neck masses with a mean size of 3.3 cm (1.2-6.0 cm), and the mean duration of the symptom was 4 years (5 months-8 years). Of the other two, one had laryngeal discomfort for 2 months, and the other one was diagnosed through a fine needle aspiration follow-up. One of the 15 patients had hyperthyroidism whereas the others had euthyroidism. The thyroid scans for 10 of them showed cold nodules. The operations consisted of a unilateral lobectomy in 2 cases, a unilateral lobectomy and isth mectomy in 11 cases, a unilateral lobectomy, isthmectomy and contralateral partial lobectomy in 1 case, and a total thyroidectomy and neck lymph node dissection in the 1 case that was combined with a papillary carcinoma. Thirteen patients (86.7%) had a H rthle cell adenoma, and two of them (13.3%) had a H rthle cell carcinoma. The mean duration of follow-up was 33 months (range 1 month-12 years), and no recurrence or death occurred during the follow-up period. CONCLUSIONS: The incidence of H rthle cell neoplasms is higher in women and the sex ratio is 1:2.8. The incidence of H rthle cell carcinomas among H rthle cell neoplasms is 13.3% (2/15). We found no specific clinical features for differentiating a H rthle cell adenoma from a H rthle cell carcinoma and no factors for adequate operative methods and prognosis due to the rarity of the condition and the short duration of the follow-up. Because of the low incidence of H rthle cell neoplasms and our limited experience, not only co-research of centers but also pathologic research is needed.
