Factors Affecting Tumor Ablation during High Intensity Focused Ultrasound Treatment.
- Author:
Aizan HASSANUDDIN
1
;
Jun Ho CHOI
;
Dong Wan SEO
;
Choong Heon RYU
;
Su Hui KIM
;
Do Hyun PARK
;
Sang Soo LEE
;
Sung Koo LEE
;
Myung Hwan KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. dwseoamc@amc.seoul.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
High-intensity focused ultrasound ablation;
Cysts;
Metal stent;
Phantom
- MeSH:
Adenocarcinoma/*therapy;
High-Intensity Focused Ultrasound Ablation/*methods;
Humans;
Models, Anatomic;
Pancreatic Neoplasms/*therapy;
Phantoms, Imaging;
Stents
- From:Gut and Liver
2014;8(4):433-437
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. METHODS: HIFU was delivered to the phantom models implanted with foreign bodies, and the location, shape, and size of the ablated zones were evaluated. RESULTS: Bone and metallic plates reflected the ultrasound beam, shifting the ablation zone from the focal zone to the prefocal area. In the phantoms containing metal stent, plastic stent, and cyst, most of the ablative energy was reflected to the prefocal area by the surface, with the remainder penetrating through the phantom. The area of the ablated margins was significantly larger in size and volume than the intended focal ablation zone. CONCLUSIONS: During HIFU therapy, artificial or anatomical barriers could affect the direction of the ultrasound beams, shifting the ablation zone from the focal area to a prefocal site with a larger than expected ablation zone. These factors should be considered prior to HIFU treatment for pancreatic tumors because they could limit ablation success, in addition to causing complications.
