beta-Catenin Activated Hepatocellular Adenoma: A Report of Three Cases in Korea.
- Author:
Gi Jeong KIM
1
;
Jae Yeon SEOK
;
Hyungjin RHEE
;
Jin Young CHOI
;
Jin Sub CHOI
;
Kyung Sik KIM
;
Swan THUNG
;
Young Nyun PARK
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. young0608@yuhs.ac
- Publication Type:Case Reports
- Keywords:
Adenoma, liver cell;
Beta catenin;
Carcinoma, hepatocellular;
Glutamine synthetase
- MeSH:
Adult;
Carcinoma, Hepatocellular/*metabolism;
Female;
Humans;
Liver Neoplasms/*metabolism;
Male;
Middle Aged;
Republic of Korea;
Young Adult;
beta Catenin/*metabolism
- From:Gut and Liver
2014;8(4):452-458
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatocellular adenoma (HCA) is an uncommon benign hepatic tumor, and the use of oral contraceptives is known to contribute to the development of HCA. Recently, a genotype and phenotype classification system for HCA was suggested, and malignant transformation to hepatocellular carcinoma (HCC) was shown to be strongly associated with activating mutations in beta-catenin. Here, we report three cases of HCA in Korean patients: 7-cm, inflammatory and beta-catenin-activated HCA with HCC transformation in a 46-year-old man; 13-cm, beta-catenin-activated HCA with cytological atypia in a 23-year-old woman; and 10-cm, pigmented, inflammatory and beta-catenin-activated HCA in a 36-year-old man. All cases exhibited the nuclear expression of beta-catenin and diffuse cytoplasmic expression of glutamine synthetase upon immunohistochemical staining. All tumors were completely resected, and the patients were followed for 3 to 6 years with no evidence of local recurrence or metastasis.