Aconite induced myelo-optic neuropathy in a rabbit model.
- Author:
Kui Duk SUK
1
;
Kyung Cheol YOON
;
Jae Pil SHIN
;
Sang Ha KIM
Author Information
- Publication Type:Original Article
- Keywords: aconite; visual evoked potential; electron microscope; myelo-opticneuropathy
- MeSH: Aconitum/administration & dosage/*toxicity; Animals; Evoked Potentials, Visual/*drug effects; Injections, Intraperitoneal; Myelin Sheath/*drug effects/ultrastructure; Optic Nerve/*drug effects/ultrastructure; Optic Nerve Diseases/*chemically induced/pathology; Rabbits; Spinal Cord/*drug effects/ultrastructure
- From:Korean Journal of Ophthalmology 1994;8(2):77-82
- CountryRepublic of Korea
- Language:English
- Abstract: Aconite is a common remedy of herb doctors and is widely used in the Far East. Clinical aspects of the visual disturbance produced by this drug have been described, but little is known about its pathology. Tinctura aconiti (0.6 mg of total alkaloid/kg 2x) was administered intraperitoneally in rabbits to evaluate its toxic effects on the visual system. The alteration in the visual evoked potential following aconite injection consisted of a delay in the onset and peak latency. Histopathologically, there were damages to the myelin sheath of the visual pathway, spinal cord and peripheral nerves. These findings suggest that aconite may cause primarily myelo-optic neuropathy.
