Carney Complex: Eleven Open Heart Operations in a Single Family.
10.5090/kjtcs.2017.50.6.471
- Author:
Sung Joon HAN
1
;
Woosik HAN
;
Min Woong KANG
;
Jae Hyeon YU
;
Shinkwang KANG
;
Myung Hoon NA
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Chungnam National University School of Medicine, Korea. ts7378@cnuh.co.kr
- Publication Type:Case Report
- Keywords:
Carney complex;
Myxoma;
Familial myxoma
- MeSH:
Carney Complex*;
Cyclic AMP-Dependent Protein Kinases;
Follow-Up Studies;
Heart*;
Humans;
Myxoma;
Polymorphism, Single Nucleotide;
Recurrence
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2017;50(6):471-473
- CountryRepublic of Korea
- Language:English
-
Abstract:
Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.
