In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains.
- Author:
Jun Won CHUNG
1
;
Su Young KIM
;
Hee Jung PARK
;
Chang Su CHUNG
;
Hee Woo LEE
;
Sun Mi LEE
;
Inki KIM
;
Jhang Ho PAK
;
Gin Hyug LEE
;
Jin Yong JEONG
Author Information
- Publication Type:Original Article
- Keywords: Helicobacter pylori; Diphenyleneiodonium; Drug resistance, multiple; Anti-bacterial agents; Minimal inhibitory concentration
- MeSH: Agar; Anti-Bacterial Agents; Bacteria; Drug Resistance, Multiple; Helicobacter pylori*; Helicobacter*; In Vitro Techniques*; Methods
- From:Gut and Liver 2017;11(5):648-654
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity. METHODS: We screened a small molecule library—the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds—to identify inhibitors of H. pylori growth. The minimal inhibitory concentrations (MICs) of antibiotics against multidrug-resistant H. pylori strains were determined using the agar dilution method. RESULTS: We identified diphenyleneiodonium (DPI) as a novel anti-H. pylori agent. The MIC values for DPI were <0.03 μg/mL against all tested H. pylori strains. DPI also exhibited strong antibacterial activity against common gram-negative and gram-positive pathogenic bacteria. CONCLUSIONS: DPI may be a candidate anti-H. pylori drug for future development.
